KMID : 0379520070230040311
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Çѱ¹µ¶¼ºÇÐȸÁö 2007 Volume.23 No. 4 p.311 ~ p.319
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Effects of Lentinus edodes-powder on Serum Homocysteine Level and Homocysteine-induced Replicative Senescence
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Park Yeong-Chul
Kim Min-Hee Kim Jong-Bong
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Abstract
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Elevated blood levels of homocysteine (a sulfur-containing amino acid) have been linked to increased risk of cerebrovascular disease including Alzheimer¡¯s disease. A recent study suggests that elevated homocysteine levels may lead to replicative senescence in vitro called ¡°permanent arrest of cell cycle¡± caused by oxidative stress. In this study, serum homocysteine level in rat was reduced by Lentinus edodes-powder diet, resulting in the reduced level of oxidative stress in rat brain. In addition, homocysteine-induced replicative senescence treated with or without Lentinus edodes-powder was analyzed by population doubling in vitro. The Lentinus edodes-powder induced a increased number of population doubling in primary neuron cell isolated from rat-cerebral cortex. This indicates that Lentinus edodes-powder would delay a homocysteine-induced aging of neuron cells in brain, showing a possible role in preventing cerebrovascular diseases including Alzheimer¡¯s disease.
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KEYWORD
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Lentinus edodes, Homocysteine, Senescence, Neuron cell, Oxidative stress
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